Ready to stop suffering from erectile dysfunction once and for all?

Decided that you’re going to try Sildenafil or Vardenafil to cure your symptoms?


Before you start living life and enjoying sex again, you’ll need to make a choice between these two treatments.

They both have their own uses, pros, and cons, so it’s wise to understand the differences before choosing one.

That’s why we’ve put this Vardenafil vs Sildenafil guide together for you.

Follow along if you’d like to learn the differences between these two drugs.

What is Sildenafil?

Sildenafil is a drug used to treat erectile dysfunction and other sexual disorders.

It is normally sold under the name Viagara, which you probably know it as. It will usually onset within 20 minutes and lasts for two hours. This is perfect for any guy that needs a quick pick-me-up versus an effect that can last for 24+ hours like other drugs

So, how does Sildenafil work?

Well, this drug blocks something known as phosphodiesterase 5. This enzyme breaks down cGMP, which is responsible for regulating blood flow to the penis. Obviously you want as much blood flow to the penis to help with getting and sustaining erections, so Sildenafil solves this problem from the root.

The drug was originally discovered in 1989 when the pharmaceutical company Pfizer was researching a chest pain medication. It was approved both in Europe and the United States during 1998.  There are approximately two million prescriptions of Sildenafil written ever year, and it’s considered a generic medication. You can even get it over the counter in the UK.

Sildenafil uses

The main use of Viagra is for sexual dysfunctions like erectile dysfunction.

This assists men in being able to get and sustain healthy erections, which as a byproduct boosts confidence, improves relationships, and helps them get back to living a normal life again.

The Clinical Interventions in Aging did an overview study in 2006 that covered the incredible amounts of data on Sildenafil’s use for treating ED. They found that over 30 million men were treated worldwide with this drug, and over 2,600 scientific papers were completed on it.

And that was back in 2006!

Besides sexual dysfunction, Sildenafil is also used for pulmonary hypertension, and has been shown to improve markers for the illness.

Sildenafil side effects

Just like any drug, there can be side effects depending on how your body reacts to it, if you’re taking other medications, and different factors.

The most common side effects include:

  • Headaches
  • Flushing of the skin
  • Congestion
  • Indigestion
  • Vision problems
  • Prolonged erections
  • Low blood pressure
  • High blood pressure
  • Hearing loss

This side effects are rare, but do happen to some gentlemen. That’s why it’s also recommended to consult with a trained medical professional to determine if you’re in the position to take an ED drug like this.

Sildenafil dosage

The recommended starting dose for Sildenafil is 50mg if the patient is trying to resolve the syptoms of erectile dysfunction.

However, this dose can also be increased to 100mg for improved effects.

The above study found that in an eight week study that men who took 50mg and 100mg experienced little to no differences in terms of function and sexual enjoyment.

Study on Slidenafil

Based on data like this, it’s best to start with a dose of 50mg to determine how you react to it, and increase this amount if you believe it’s safe and needed.

Is Sildenafil legal?

In Canada, Australia, and the United States, Sildenafil is only available with a medical prescription.

It’s completely legal in most places around the world, but make sure that you have been prescribed it.

Since visiting the doctor’s can be embarrassing for situations like this, there are services like Bluechew that will deliver Sildenafil to your door.

Is Sildenafil safe?

Yes, Sildenafil is a safe drug to treat ED with.

In fact, a study performed in 2007 looked at the long term effects of the drug since most patients tend to use it for long periods.

The four year long study took men who already completed one to four double blind trials. They would be put on 25mg, 50mg, and 100mg doses to determine the safety and effectiveness through continued use

There were 979 participants with a mean age of 58, but they ranged from 27-82. They had erectile dysfunction for 4.5 years on average.

3.8% of these participants had non-serious adverse effects that required them to change dose. 6.3% discontinued their use of Sildenafil because of lacking results, and 94% responded positively when asked if they were satisfied with treatment at each yearly assessment.

There are plenty of scientific studies just like this that point to the safety and effectiveness of this drug.

Sildenafil brands

Sildenafil is sold under many different brand names with some of the most popular being:

  • Viagara
  • Bluechew
  • Accord
  • Actavis
  • Ajanta
  • Aurobindo
  • Bristol Labs
  • Dr Reddy’s
  • Consilient
  • Pfizer
  • Mylan
  • Teva
  • Sandoz
  • Torrent
  • Zentiva

With Sildenafil ‘s information covered, let’s now look at Vardenafil and how it differs.

What is Vardenafil?

Vardenafil is a drug used in the treatment of erectile dysfunction. A study in 2010 concluded that it is “effective and well-tolerated.”


It works very similar to Sildenafil in the regard that it’s a PDE5 inhibitor. This blocks the enzyme that prevents blood flow from entering the penis, hence allowing you to get and sustain healthier erections.

It was originally marketed by the companies Bayer Pharmaceuticals, Scherig-Plough, and GlaxoSmithKline under the brand name Livtra.

But what makes it different?

Firstly, the nitrogen atom position in Sildenafil is different and it has a piperazine ring methyl group versus an ethyl group in Vardenafil.

Vardenafil can also help men with premature ejaculation, which Sildenafil does not.

If you find that you are struggling to last in bed, Vardenafil can be a better choice as it solves two problems at once.

Vardenafil uses

Vardenafi is mostly used to solve the effects of erectile dysfunction and other sexual dysfunctions like premature ejaculation.

It is not used for other health issues like Sildenafil, making it slightly less versatile.

Vardenafil side effects

You will notice that the side effects of Vardenafil are very similar to the ones found with Sildenafil since the drugs work almost exactly the same. These include:

  • Nausea
  • Eye pain
  • Back pain
  • Abdominal pain
  • Hearing loss

Always consult with a doctor if you are in a good physical condition and eligible to take a drug like this.

You may have certain conditions or be taking medications that will be unsafe when used in conjunction with Vardenafil.

Vardenafil dosage

Vardenfail is typically prescribed in 2.5mg, 5mg, 10mg, or 20mg tablets.

It is always recommend to begin safe by taking a lower dose, such as 2.5mg, and building up if you wish to experience more effects.

Please remember that if you take a higher dose, you may be at a higher risk of side effects.

Is Vardenafil legal?

In the United States, Australia, and the United Kingdom, it is required for patients to have a prescription to obtain Vardenafil.

Is Vardenafil safe?

A study from 2004 took 323 patients whom randomly received a placebo or 10mg dose of Vardenafil.

They were given the option to switching to a 5mg or 20mg dose after four weeks. The placebo was also the equivalent dose.

The study concluded that “vardenafil was well-tolerated, and produced clinically relevant improvements in erectile function in men with ED.”

Vardenafil brands

You can find Vardenafil under the brand names Levitra or Staxyn.

Conclusion of Sildenafil versus Vardenafil

The key differences between these two drugs are the following:

  1. Sildenafil can be found under a dozen or more brand names, while Vardenafil also has approximately two. This makes Vardenafil much harder to find and obtain versus its competitor.
  2. Sildenafil does not help with premature ejaculation, while Vardenafil has been shown to treat this condition at the same time.

With this being said, Sildenafil is the better choice if you’re seeking a treatment strictly for ED. Those that are serious about also helping their premature ejaculation should consider Vardenafil to gain that added benefit.